의과대학 - 의과대학

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관심분야

병원균의 항생제 내성(antimicrobial resistance): 메카니즘 및 진화

학력

  • (Ph.D.) 서울대학교 생명과학부

약력/경력

  • 2007. 3 - 현재. 성균관대학교 교수
  • 2003. 5 - 현재. 아태감염연구재단(APFID) 연구실장
  • 2000. 9 - 2003. 4. 서울대학교 의과대학 미생물학교실 박사후연구원

학술지 논문

  • (2023)  Conversion to colistin susceptibility by tigecycline exposure in colistin-resistant Klebsiella pneumoniae and its implications to combination therapy.  INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS.  63,  1
  • (2023)  Roles of crrAB two-component regulatory system in Klebsiella pneumoniae: Growth yield, survival in initial colistin treatment stage, and virulence.  INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS.  63,  1
  • (2023)  Multiple heteroresistance to tigecycline and colistin in <i>Acinetobacter baumannii</i> isolates and its implications for combined antibiotic treatment.  JOURNAL OF BIOMEDICAL SCIENCE.  30,  1
  • (2023)  Reduced virulence in tigecycline-resistant <i>Klebsiella pneumoniae</i> caused by overexpression of <i>ompR</i> and down-regulation of <i>ompK35</i>.  JOURNAL OF BIOMEDICAL SCIENCE.  30,  1
  • (2023)  Improvement of transformation efficency in hypermucoviscous Klebsiella pneumoniae using citric acid.  JOURNAL OF MICROBIOLOGICAL METHODS.  205, 
  • (2022)  Overexpression of a DNA Methyltransferase Increases Persister Cell Formation in Acinetobacter baumannii.  MICROBIOLOGY SPECTRUM.  10,  6
  • (2022)  Comparison of Virulence between Two Main Clones (ST11 and ST307) of Klebsiella pneumoniae Isolates from South Korea.  MICROORGANISMS.  10,  9
  • (2022)  Comparative analysis of the Colistin resistance-regulating gene cluster in Klebsiella species.  JOURNAL OF MICROBIOLOGY.  60,  5
  • (2021)  Tigecycline heteroresistance and resistance mechanism in clinical isolates of Acinetobacter baumannii.  MICROBIOLOGY SPECTRUM.  58,  41
  • (2021)  Effect of multiple, compatible plasmids on the fitness of the bacterial host by inducing transcriptional changes.  JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY.  76,  10
  • (2021)  Two Distinct Genotypes of KPC-2-Producing Klebsiella pneumoniae Isolates from South Korea.  ANTIBIOTICS-BASEL.  10,  8
  • (2021)  The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci.  ELIFE.  10, 
  • (2021)  High concentrations of divalent cations in extracellular environments reduce in vitro antibiotic activity of tigecycline.  Journal of Bacteriology and Virology.  51,  2
  • (2021)  Detection of colistin-resistant populations prior to antibiotic exposure in KPC-2-producing Klebsiella pneumoniae clinical isolates.  JOURNAL OF MICROBIOLOGY.  59,  6
  • (2021)  Genome-Wide Analysis of the Temporal Genetic Changes in Streptococcus pneumoniae Isolates of Genotype ST320 and Serotype 19A from South Korea.  MICROORGANISMS.  9,  4
  • (2021)  Clinical Impact of Revised Ciprofloxacin Breakpoint in Patients with Urinary Tract Infections by Enterobacteriaceae.  ANTIBIOTICS-BASEL.  10,  4
  • (2021)  A bacterial strain with the deletion of a prophage gene only in the plasmid also showed diminished antibiotic resistance.  INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS.  57,  3
  • (2020)  Functional Identification of Serine Hydroxymethyltransferase as a Key Gene Involved in Lysostaphin Resistance and Virulence Potential of Staphylococcus aureus Strains.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.  21,  23
  • (2020)  Change of Hypermucoviscosity in the Development of Tigecycline Resistance in Hypervirulent Klebsiella pneumoniae Sequence Type 23 Strains.  MICROORGANISMS.  8,  10
  • (2020)  Two types of colistin heteroresistance inAcinetobacter baumanniiisolates.  EMERGING MICROBES & INFECTIONS.  9,  1

단행본

  • (2009)  Prescot의 핵심미생물학.  지코사이언스.  공동

수상/공훈

  • 2012. SKKU (Sungkyunkwan University) Fellowship
  • 2003. The 13rd Outstanding Publication Award (The Korean Federation of Science and Technology Societies)

학술회의논문

  • (2008)  Extreme-drug resistance (XDR) in Acinetobacter baumannii from intensive care units in Korea.  WPCCID.  대만
  • (2008)  Increase of serotypes 19A, 15, and 14 in Streptococcus pneumoniae isolates from a Korean hospital in 2007.  WPCCID.  대만
  • (2008)  Characterisitcs of community-onset ciprofloxacin-resistant Escherichia coli isolates causing urinary tract infections in Korea.  2008 대한감염학회, 대한화학요법학회 추계학술대회.  대한민국
  • (2008)  Comparison of ST72 community-associated and healthcare-associated MRSA isolates from Korea.  2008 대한감염학회, 대한화학요법학회 추계학술대회.  대한민국
  • (2008)  Extreme drug resistance (XDR) in Acinetobacter baumannii from intensive care units in Korea.  2008 대한감염학회, 대한화학요법학회 추계학술대회.  대한민국
  • (2008)  Genotypic characteristics of ESBL-producing Klebsiella pneumoniae isolates causing bacteremia and urinary tract infections in Korea.  2008 대한감염학회, 대한화학요법학회 추계학술대회.  대한민국
  • (2008)  미동정 균주의 염기서열 분석을 이용한 동정.  2008 대한감염학회, 대한화학요법학회 추계학술대회.  대한민국
  • (2008)  Genotypic characteristics of ESBL-producing Klebsiella pneumoniae isolates causing bacteremia and urinary tract infections in Korea.  2008 ICAAC/IDSA joint meeting.  미국
  • (2008)  Independent emergence of colistin-resistant Acinetobacter isolates from Korea.  2008 ICAAC/IDSA joint meeting.  미국
  • (2008)  Two distinct clones of carbapenem-resistant Acinetobacter baumannii isolates from Korean hospitals.  2008 ICAAC/IDSA joint meeting.  미국
  • (2008)  Change of clones and serotypes of Streptococcus pneumoniae isolates between 1998 and 2007 in a Korean tertiary-care hospital.  17th Internatioal Congress of Tropical Medicine and Malaria.  대한민국
  • (2008)  Incorrect identification of Streptococcus pneumoniae and its effect on antimicrobial resistance rates.  17th Internatioal Congress of Tropical Medicine and Malaria.  대한민국
  • (2008)  Indepedent emergence of colistin-resistant Acinetobacter spp. isolates from Korea.  17th Internatioal Congress of Tropical Medicine and Malaria.  대한민국
  • (2008)  Molecular characteristics of methicillin-resistant Staphylococcus aureus: clonality and difference.  17th International Congress of Tropical Medicine and Malaria.  대한민국
  • (2008)  Two distinct clones of carbapenem-resistant Acinetobacter baumannii isolates from Korean hospitals.  17th Internatioal Congress of Tropical Medicine and Malaria.  대한민국
  • (2008)  Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) in Asian countries including Korea.  2008년 제5차 대한미생물학회 하계네트워킹심포지움.  대한민국
  • (2007)  In vitro effectiveness of the antibiotic lock technique (ALT) for the treatment of catheter-related infections by Pseudomonas aeruginosa and Klebsiella pneumoniae.  Interscience Conference on Antimicrobial Agents and Chemotherapy.  미국
  • (2007)  High resistance rate of colistin and polymyxin B in particular subgroups of Acinetobacter baumannii isolates from Korea.  47th Interscience Conference on Antimicrobial Agents and Chemotherapy.  미국
  • (2007)  Is teicoplanin effective against VanB-type vancomycin-resistant Enterococcus faecium with vanA gene?.  Interscience Conference on Antimicrobial Agents and Chemotherapy.  미국
  • (2007)  Prevalence and characterization of extended-spectrum beta-lactamase-producing Enterobactereiaceae in Korean hospitals.  ISAAR.  싱가포르